Francisco J. P. Lopes

The paper identifies a geometric control principle in non-conservative gene regulatory networks that determines phenotypic transitions in breast cancer by analyzing phase-space distances and bifurcation structures.

This study shows that restoring ribosomal homeostasis by targeting RNAse P/MRP or mitochondrial ribosome extends lifespan in C. elegans by improving proteostasis and ribosome assembly.

The paper models NF-κB epigenetic variability in breast cancer, showing it drives subtype transitions and heterogeneity through attractor basins.

This study uses RNA-seq to assess the transcriptional effects of cisplatin and TiO2 nanoparticles in Drosophila, finding synergistic gene suppression and impaired climbing performance in combined exposure.

The paper develops a reaction-diffusion model to show Cactus/IκB has a dual role in regulating Dorsal/NFκB nuclear translocation in Drosophila embryos.