Edward Anderton

This study shows that human brain aging involves asymmetric remodeling of the insoluble proteome, with intermediate-stability aggregates accumulating and being linked to neurodegenerative disease.

This study shows that restoring ribosomal homeostasis by targeting RNAse P/MRP or mitochondrial ribosome extends lifespan in C. elegans by improving proteostasis and ribosome assembly.

This study shows that amyloid β accelerates age-related protein insolubility in C. elegans and links this process to neurodegenerative and age-related diseases through proteomics and GWAS.

This study shows that sleep disruption in mice increases cellular senescence in visceral adipose tissue, leading to oxidative stress and DNA damage, which may accelerate aging and age-related diseases.