Time Resolved Inspection of Ionizable-Lipid Facilitated Lipid Nanoparticle Disintegration and Cargo Release at an Endosomal Membrane Mimic
Nima Aliakbarinodehi, Simon Niederkofler, Gustav Emilsson, Petteri Parkkila, Erik Olsén, Yujia Jing, Mattias Sjöberg, Björn Agnarsson, Lennart Lindfors, Fredrik Höök
This study uses TIRF imaging to examine pH-induced LNP fusion and mRNA release, showing delayed fusion onset and rapid cargo escape, with implications for optimizing mRNA delivery.
ACS Nano · Aug 12, 2024Peer-reviewedBiophysics