Lennart Lindfors

Targeted delivery of mRNA to the heart via extracellular vesicles or lipid nanoparticles

This study compares the efficiency of cardiac-specific extracellular vesicles and lipid nanoparticles in delivering mRNA to the heart, finding that cardiac-specific vesicles are more effective with less liver accumulation.

Cellular and biophysical barriers to lipid nanoparticle mediated delivery of RNA to the cytosol

This study identifies multiple barriers to efficient cytosolic delivery of RNA by lipid nanoparticles, including endosomal sorting and membrane damage mechanisms.

Time Resolved Inspection of Ionizable-Lipid Facilitated Lipid Nanoparticle Disintegration and Cargo Release at an Endosomal Membrane Mimic

This study uses TIRF imaging to examine pH-induced LNP fusion and mRNA release, showing delayed fusion onset and rapid cargo escape, with implications for optimizing mRNA delivery.