Chris German

The paper analyzes the impact of CYP2C19 genotype on SSRI side effects and discontinuation rates in a large sample of individuals.

This study finds that higher polygenic risk scores for breast cancer are associated with longer survival in patients, suggesting a link between genetic predisposition and less aggressive tumors.

This study uses a multivariate GWAS approach to identify genetic loci associated with reading ability and dyslexia, finding 35 new genome-wide significant loci and estimating SNP heritability at 24%.

PRSformer predicts disease risk from large-scale genotypes using deep learning, outperforming linear models and summary-statistic methods in multi-ancestry cohorts.

This study identifies genetic correlations between hyposmia and Parkinson's disease, finding a strong causal link from PD to hyposmia but weaker evidence for the reverse.

This study investigates the shared genetic architecture between rhythm and dyslexia using large-scale genome-wide association studies.

This paper uses a polygenic risk score to identify undiagnosed diabetes cases, finding that combining BMI and PRS captures most undiagnosed cases, including those with normal weight.

This paper introduces an improved iterative hard thresholding method for GWAS that enhances true positive rates and reduces false positives compared to traditional approaches.