3D Mapping of Intact Ovaries Reveals the Aging Dynamics of the Ovarian Reserve
Arturo D’Angelo, Daniel Franco-Barranco, Marco Musy, James A. Sharpe, Ignacio Arganda‐Carreras, Elvan Böke
This study maps over 85,000 oocytes in mouse ovaries across their reproductive lifespan, revealing spatial patterns and a bimodal size distribution, along with a mathematical model of oocyte activation and loss.
bioRxiv · Nov 7, 2025 · PreprintCell Biology