Carlo Carolis

This paper characterizes DO1Cas9, a cold-adapted Cas9 nuclease from the deep ocean, showing improved activity under cold conditions and broader organismal applicability.

This study identifies potent antimalarial antibodies in African infants vaccinated with RTS,S/AS01E, showing near-germline configurations and protective efficacy.

This study evaluates the immunomodulatory effects of ivermectin in mild COVID-19 patients and finds no significant immune response changes, consistent with clinical trial results.

This paper introduces EvolveX, a computational pipeline for designing stable single-domain antibodies with high affinity, demonstrating improved binding affinity to human targets.

This study demonstrates the use of SpG and SpRY CRISPR-Cas9 variants in zebrafish and C. elegans for genome editing, showing improved accessibility to previously uneditable sites.

The paper applies controlled forces to microparticles in embryos to measure tissue mechanical properties and finds a rapid softening during Drosophila cellularization.