Marco Musy

LimbLab: Pipeline for 3D Analysis and Visualisation of Limb Bud Gene Expression

LimbLab provides a pipeline for 3D analysis and visualization of limb bud gene expression data, improving workflow efficiency and compatibility with existing tools.

3D Mapping of Intact Ovaries Reveals the Aging Dynamics of the Ovarian Reserve

This study maps over 85,000 oocytes in mouse ovaries across their reproductive lifespan, revealing spatial patterns and a bimodal size distribution, along with a mathematical model of oocyte activation and loss.

Self-organized mechanochemical instabilities drive the emergence of digit tissue morphogenesis

The paper develops a limb-mesenchymal organoid system and models to show that digit-like structures form through mechanochemical instabilities involving cell adhesion, chemotaxis, and convergent-extension.

Cell 3D Positioning by Optical encoding (C3PO) and its application to spatial transcriptomics

C3PO reconstructs 3D cell positions after dissociation, enabling spatial transcriptomics with 3D structure preservation.

4D reconstruction of developmental trajectories using spherical harmonics

This paper introduces a method to reconstruct 4D developmental trajectories from 3D images using spherical harmonics, demonstrating its application to mouse limb buds and hearts.

Cellular mechanisms of chick limb bud morphogenesis

This study identifies cell intercalation as the primary driver of chick limb bud morphogenesis, using in vivo imaging and computational modeling to reveal the role of molecular gradients and tissue fluidity.