SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike-ACE2 receptor interaction
Eduardo A. Albornoz, Alberto Anastacio Amarilla, Naphak Modhiran, Sandra E. Parker, Xaria X. Li, Danushka K. Wijesundara, Adriana C. Pliego Zamora, Christopher L. D. McMillan, Benjamin Liang, Nias Y. G. Peng, Julian D. J. Sng, Fatema Tuj Saima, Devina Paramitha, Rhys H. Parry, Michael Selorm Avumegah, , Trent M. Woodruff
This study shows SARS-CoV-2 activates microglial NLRP3 inflammasome via spike-ACE2 interaction, potentially linking viral infection to neurological symptoms like Parkinson's.
bioRxiv · Jan 11, 2022 · PreprintNeuroscience