Clarissa Stephanie Santoso

The paper uses peptide tiling to identify viral protein regions that modulate stress-induced cell death in U2OS cells, revealing modular regulatory functions.

This study systematically profiles 95 viral transcriptional regulators (vTRs) across multiple assays, revealing their diverse mechanisms of rewiring host pathways to promote viral replication and disease links.

The paper identifies two categories of transcription factor isoforms with distinct molecular functions and shows they contribute to gene regulatory complexity.

The paper introduces paired yeast one-hybrid assays to detect DNA-binding cooperativity and antagonism between transcription factors and demonstrates their application across various TF pairs.

The paper develops enhanced yeast one-hybrid assays to study TF binding to repetitive elements, variants, and novel motifs, identifying 75 TFs interacting with Alu elements and changes in TF binding associated with cancer-related mutations.