Luis F. Soto-Ugaldi

A commensally regulated immune rheostat fine-tunes skin barrier fitness

This study identifies a microbial-immune-epithelial feedback mechanism that regulates stem cell activity and skin barrier function through prostaglandin E2 signaling.

Peptide tiling across viral proteomes identifies modular regulators of stress-induced cell death

The paper uses peptide tiling to identify viral protein regions that modulate stress-induced cell death in U2OS cells, revealing modular regulatory functions.

fastCDS: proteome-scale mapping of protein domains to genomic coordinates

fastCDS maps protein domains to genomic coordinates efficiently, enabling rapid analysis of exonic architecture and variant interpretation.

Multilayered specificity of transcription factor binding at cytokine promoters

The paper identifies TF-DNA binding interactions at cytokine promoters, showing that TF cooperativity and antagonism significantly influence DNA-binding specificity.

Atlas of HIV cis-regulatory elements reveals extensive transcriptional variation across clades, isolates, and within individuals

The paper creates a regulatory atlas of HIV-1 and HIV-2 by analyzing transcriptional variation across clades, isolates, and individuals using MPRAs and predictive models.

Global cis-regulatory landscape of double-stranded DNA viruses

The paper identifies ~2,000 cis-regulatory elements (CREs) across 27 dsDNA viruses using reporter assays and machine learning, revealing their regulatory features and associated transcription factors.

Paired yeast one-hybrid assays to detect DNA-binding cooperativity and antagonism across transcription factors

The paper introduces paired yeast one-hybrid assays to detect DNA-binding cooperativity and antagonism between transcription factors and demonstrates their application across various TF pairs.