Ryan Lane

The paper identifies TF-DNA binding interactions at cytokine promoters, showing that TF cooperativity and antagonism significantly influence DNA-binding specificity.

This study systematically profiles 95 viral transcriptional regulators (vTRs) across multiple assays, revealing their diverse mechanisms of rewiring host pathways to promote viral replication and disease links.

The paper identifies two categories of transcription factor isoforms with distinct molecular functions and shows they contribute to gene regulatory complexity.

This study constructs a large-scale cancer-specific TF-DNA interaction network and identifies potential therapeutic targets among oncogenes and TFs.

The paper introduces paired yeast one-hybrid assays to detect DNA-binding cooperativity and antagonism between transcription factors and demonstrates their application across various TF pairs.