Alicia M. Hall

Excitoprotective effects of conditional tau reduction in excitatory neurons and in adulthood

This study generates a conditional tau knockout model and shows that tau reduction in excitatory neurons provides excitoprotective effects, while reduction in inhibitory neurons increases seizure susceptibility, even when induced in adulthood.

NRSF-mediated repression of neuronal genes in developing brain persists in the absence of NRSF-Sin3 interaction

The paper investigates whether NRSF-Sin3 interaction is required for NRSF-mediated repression of target genes in developing hypothalamus and finds that blocking this interaction does not prevent repression.