Rose B. Creed

This study evaluates hTau.P301S mice for PSP-like features, finding motor and eye movement impairments linked to Tau pathology.

This study generates a conditional tau knockout model and shows that tau reduction in excitatory neurons provides excitoprotective effects, while reduction in inhibitory neurons increases seizure susceptibility, even when induced in adulthood.

This study shows that chronic hyperactivation of midbrain dopamine neurons leads to their preferential degeneration, suggesting increased neural activity may contribute to Parkinson's disease pathology.