M. Natalie Davis

Excitoprotective effects of conditional tau reduction in excitatory neurons and in adulthood

This study generates a conditional tau knockout model and shows that tau reduction in excitatory neurons provides excitoprotective effects, while reduction in inhibitory neurons increases seizure susceptibility, even when induced in adulthood.

MAPT expression is mediated by long-range interactions with cis-regulatory elements

The paper identifies cis-regulatory elements (cCREs) controlling MAPT expression and links genetic variation in these elements to Alzheimer's disease risk.

An improved CRISPR/dCas9 interference tool for neuronal gene suppression

This paper improves CRISPR/dCas9 interference for neuronal gene suppression by using a dual lentivirus system and dCas9-KRAB-MeCP2 construct, showing superior repression of the Bdnf gene in rat neurons.