Nancy V. N. Carullo

This study generates a conditional tau knockout model and shows that tau reduction in excitatory neurons provides excitoprotective effects, while reduction in inhibitory neurons increases seizure susceptibility, even when induced in adulthood.

The paper develops a Cre-dependent CRISPR-dCas9 system for gene regulation in neurons, showing improved specificity over traditional methods.

This paper improves CRISPR/dCas9 interference for neuronal gene suppression by using a dual lentivirus system and dCas9-KRAB-MeCP2 construct, showing superior repression of the Bdnf gene in rat neurons.

This study investigates the role of Gadd45b in dopamine-dependent transcription and cocaine reward, showing its necessity for cocaine-induced behavioral and epigenetic changes.

The paper identifies enhancer-gene regulatory links using eRNAs and shows their functional importance in neuronal systems.

This study shows that increased BIN1 expression in neurons leads to hyperexcitability, which is modulated by Tau, suggesting a role for BIN1 in Alzheimer's disease pathogenesis.