Neuroticism is linked to cognitive decline and increased risk of Alzheimer's disease through dysregulation of excitatory neurons
Sneha Sharma, Natacha Comandante-Lou, Yiyi Ma…·Philip L. De Jager
The paper identifies two genes, ADRA1B and LY6E-DT, downregulated in excitatory neurons associated with neuroticism and found to partially mediate the risk of Alzheimer's disease.