Characterizing Post-Mortem Brain Molecular Taxonomy of Cognitive Resilience and Translating it to Living Humans
Caio M.P.F. Batalha, Lei Yu, Andrea R. Zammit, Victoria N. Poole, Aron S. Buchman, Kátia de Paiva Lopes, Ricardo A. Vialle, Peter M. Abadir, Lolita S. Nidadavolu, Tony Wyss‐Coray, Nicholas T. Seyfried, Yanling Wang, Shinya Tasaki, Philip L. De Jager, Yasser Iturria‐Medina, David A. A Bennett
The paper defines cognitive resilience as differential cognitive decline rates after adjusting for neuropathologies, develops a framework to quantify it using molecular signatures from post-mortem brain data, and translates these findings to living individuals.
bioRxiv · Aug 13, 2025 · PreprintNeuroscience