Timothy A. Evans

Evolutionary conservation of midline axon guidance activity between Drosophila and Tribolium Frazzled

This study shows that Tribolium Frazzled can substitute for Drosophila Frazzled in promoting midline axon crossing, suggesting conserved mechanisms in insect axon guidance.

Evolutionary conservation of midline repulsive signaling by Robo family receptors inflies and mice

This study shows that Robo family receptors from mice can partially rescue midline repulsion in fruit flies, suggesting conserved core mechanisms but also evolutionary divergence.

Slit-independent guidance of longitudinal axons by Drosophila Robo3

This study shows that Drosophila Robo3 guides longitudinal axons without requiring Slit, despite needing its Ig1 domain for Slit binding and axonal localization.

Characterization of enhancer fragments in Drosophila robo2

The paper identifies enhancer fragments in Drosophila robo2 that regulate its expression in specific neural cell types and describes their activity in embryonic tissues.

The Slit-binding Ig1 domain is required for multiple axon guidance activities of Drosophila Robo2

This study shows that the Slit-binding Ig1 domain of Drosophila Robo2 is essential for midline repulsion and lateral axon pathway formation, and its removal disrupts these functions.

Conserved and divergent aspects of Robo receptor signaling and regulation between Drosophila Robo1 and C. elegans SAX-3

This study compares midline repulsive signaling of Drosophila Robo1 and C. elegans SAX-3 using transgenic expression, showing SAX-3 can signal repulsion but less efficiently than Robo1.

Minimal structural elements required for midline repulsive signaling and regulation of Drosophila Robo1

This study identifies the minimal ectodomain structure of Drosophila Robo1 required for Slit binding and midline repulsive signaling, showing that Ig1 plus one additional domain is sufficient for full function.