Pharmacology & ToxicologyJournal of Medicinal ChemistryPeer-reviewed
Fragment-based development of small molecule inhibitors targeting Mycobacterium tuberculosis cholesterol metabolism
Madeline E. Kavanagh, Kirsty J. McLean, Sophie H. Gilbert…·Anthony G. Coyne
This paper develops small molecule inhibitors targeting Mtb cholesterol oxidases CYP125 and CYP142, showing potent antimicrobial activity against drug-susceptible and MDR-TB strains.