Cancer BiologybioRxivPreprint
Pyrimethamine inhibits mutant NRF2 as a molecular glue
Zhaohui Xiong, Chorlada Paiboonrungruang, Hai‐Ning Wang…·Xiaoxin Luke Chen
This study shows that pyrimethamine inhibits mutant NRF2 by acting as a molecular glue to restore KEAP1 binding, enhancing therapy sensitivity in ESCC.
DOI 10.1101/2025.08.18.670902