Pyrimethamine inhibits mutant NRF2 as a molecular glue
Zhaohui Xiong, Chorlada Paiboonrungruang, Hai‐Ning Wang, Boopathi Subramaniyan, Candice Bui-Linh, Yahui Li, Huan Li, Francis J. Spitz, Xiaoxin Luke Chen
This study shows that pyrimethamine inhibits mutant NRF2 by acting as a molecular glue to restore KEAP1 binding, enhancing therapy sensitivity in ESCC.
bioRxiv · Aug 18, 2025 · PreprintCancer Biology