Xiaoxin Luke Chen

Integrated multi-omics reveals adaptive anti-oxidant remodeling in early alcohol-associated liver disease

This study integrates multi-omics data from alcohol-fed mice to reveal metabolic and epigenetic changes in early alcohol-associated liver disease, highlighting a shift toward antioxidant responses.

Loss of Propionyl-CoA Carboxylase Reprograms Hepatic Metabolism by Suppressing Mitochondrial Pyruvate Carboxylation and Fatty Acid Oxidation

This study investigates metabolic changes in PCCA-deficient hepatocytes, showing reduced fatty acid oxidation and pyruvate carboxylation, leading to impaired gluconeogenesis and lipid synthesis.

Pyrimethamine inhibits mutant NRF2 as a molecular glue

This study shows that pyrimethamine inhibits mutant NRF2 by acting as a molecular glue to restore KEAP1 binding, enhancing therapy sensitivity in ESCC.

Pyrimethamine and a potent analogue WCDD115 inhibit NRF2 by suppressing DHFR and one-carbon metabolism

This paper identifies Pyrimethamine and its derivative WCDD115 as potent inhibitors of NRF2 by targeting DHFR and one-carbon metabolism, with WCDD115 showing 22-fold greater efficacy.

Loss of a novel striated muscle-enriched mitochondrial protein Coq10a enhances postnatal cardiac hypertrophic growth

This study shows that loss of Coq10a, a muscle-enriched mitochondrial protein, enhances postnatal cardiac hypertrophy without impairing cardiac function.