Pioneer factor IRF1 unlocks latent enhancers to rewire chromatin and immunometabolism in inflammatory macrophages
Jose-Mauricio Ayala, Rebecca Bellworthy, Mathieu Mancini, Ana Victoria Ibarra‐Meneses, Christopher Fernandez‐Prada, David Langlais
This study identifies IRF1 as a pioneer factor that remodels chromatin and drives metabolic reprogramming in inflammatory macrophages through enhancer activation and transcriptional control.
bioRxiv · Feb 27, 2026 · PreprintGenomics