David Langlais

This study shows that USP15 deletion in astrocytes and microglia reduces neuroinflammation and slows synucleinopathy progression in mice, with human data linking USP15 expression to Parkinson's disease risk.

This study shows that immune receptors on hematopoietic progenitor cells are upregulated in a mouse model of rheumatoid arthritis and that stimulating these receptors alters cell expansion and differentiation.

This study identifies IRF1 as a pioneer factor that remodels chromatin and drives metabolic reprogramming in inflammatory macrophages through enhancer activation and transcriptional control.

The paper develops a genome assembly pipeline to analyze Borrelia burgdorferi strains, revealing genomic diversity at telomeres and plasmids across Canadian isolates.

This study shows Leishmania parasites use extrachromosomal DNA amplification to adapt to drug pressure, with linear and circular amplicons forming through recombination events.

This study identifies IRF-5 as essential for maintaining mitochondrial function and oxidative phosphorylation in CD8 T cells during chronic LCMV Cl13 infection, preventing functional exhaustion and cell death.

This study shows low dose methotrexate (LD-MTX) differentially affects cycling and resting human hematopoietic stem and progenitor cells (HSPC), reducing proliferation while preserving clonogenicity in non-cycling cells.

This study shows that trained immunity affects dendritic cell differentiation and function in rheumatoid arthritis, altering their gene expression and immune responses.