Author

Jose-Mauricio Ayala

McGill UniversityORCID 0000-0001-9030-3694Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:ATAC-seq· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:Hi-C· 1 Assay:long-read sequencing· 1 Organism:mouse· 1

Frequent Co-Authors

Ana Victoria Ibarra‐MenesesiD· 1 shared Christopher Fernandez‐PradaiD· 1 shared David LanglaisiD· 1 shared Mathieu ManciniiD· 1 shared Rebecca BellworthyiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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5 top collaborators · 10 mutual co-author links

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1 shared paperGenomics

Ana Victoria Ibarra‐MenesesORCID

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1 paper

Recent·Most cited

GenomicsbioRxivPreprintFeb 27, 2026

Pioneer factor IRF1 unlocks latent enhancers to rewire chromatin and immunometabolism in inflammatory macrophages

Jose-Mauricio Ayala, Rebecca Bellworthy, Mathieu Mancini…·David Langlais

This study identifies IRF1 as a pioneer factor that remodels chromatin and drives metabolic reprogramming in inflammatory macrophages through enhancer activation and transcriptional control.

DOI 10.64898/2026.02.27.708404

mouseATAC-seq

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