Author

Ajeet K. Sharma

Pennsylvania State UniversityORCID 0000-0002-2819-1668Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Organism:yeast· 2 Research Focus:differential expression· 1 Organism:mouse· 1 Assay:Ribo-seq· 1

Frequent Co-Authors

Edward P. O’BrieniD· 2 shared Günter KrämeriD· 1 shared Nabeel AhmediD· 1 shared Pietro SormanniiD· 1 shared Prajwal CiryamiD· 1 shared Ulrike Anne FriedrichiD· 1 shared

Activity by Year

2018-2019 · peak 1/yr

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6 top collaborators · 15 mutual co-author links

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2 shared papersBioinformatics

Edward P. O’BrienORCID

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2 papers

Recent·Most cited

BioinformaticsPLoS Computational BiologyPeer-reviewedMay 23, 2019

A Chemical Kinetic Basis for Measuring Translation Initiation and Elongation Rates from Ribosome Profiling data

Ajeet K. Sharma, Pietro Sormanni, Nabeel Ahmed…·Edward P. O’Brien

The paper develops chemical kinetic methods to measure translation initiation, elongation, and codon-specific rates from ribosome profiling data, finding significant variability in codon translation rates.

68 citations

yeastmouse

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BiophysicsbioRxivPreprintDec 8, 2018

Combinations of slow translating codon clusters can increase mRNA half-life

Ajeet K. Sharma, Edward P. O’Brien

The paper shows that two slow codon clusters can increase mRNA half-life by suppressing ribosome queues, contrasting the effect of a single cluster.

DOI 10.1101/490995

yeaststatistical model

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