Author

Vamseedhar Rayaprolu

La Jolla Institute for ImmunologyORCID 0000-0002-2823-2984Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:cryo-EM· 1 Approach:statistical model· 1 Organism:virus· 1

Frequent Co-Authors

Alain R. Townsend· 1 shared Alexandra LucasiD· 1 shared Amar D. ParvateiD· 1 shared Ariane BalaramiD· 1 shared Chitra HariharaniD· 1 shared Daniel J. LightwoodiD· 1 shared Dipti Parekh· 1 shared Erica Ollmann SaphireiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperImmunology

Alain R. Townsend

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2 papers

Recent·Most cited

A broadly-neutralizing antibody against Ebolavirus glycoprotein that potentiates the breadth and neutralization potency of other antibodies

Francesca R. Donnellan, Vamseedhar Rayaprolu, Pramila Rijal, Victoria O’Dowd, Amar D. Parvate, Heather Callaway, Chitra Hariharan, Dipti Parekh, Sean Hui, Kelly C. L. Shaffer, Rubén Díaz-Avalos, Kathryn M. Hastie, Lisa M. Schimanski, Helena Müller-Kräuter, Thomas Strecker, , Simon J. Draper

The paper identifies two broadly neutralizing antibodies against Ebolavirus glycoprotein and shows that one enhances the neutralization breadth and potency of other antibodies.

npj Viruses · May 7, 2026Peer-reviewedImmunology

Long-range allosteric communication, double mutant cycles, and energetic coupling in SARS-CoV-2 spike protein

Alexandra Lucas, Vamseedhar Rayaprolu, Krishna M.G. Mallela

The paper investigates how mutations in the N-terminal domain (NTD) of SARS-CoV-2 spike protein affect conformational states and interactions with ACE2 and antibodies, revealing long-range allosteric communication and energetic coupling.

bioRxiv · Apr 22, 2026 · PreprintBiophysics