BiophysicsbioRxivPreprint
Long-range allosteric communication, double mutant cycles, and energetic coupling in SARS-CoV-2 spike protein
Alexandra Lucas, Vamseedhar Rayaprolu, Krishna M.G. Mallela
The paper investigates how mutations in the N-terminal domain (NTD) of SARS-CoV-2 spike protein affect conformational states and interactions with ACE2 and antibodies, revealing long-range allosteric communication and energetic coupling.