This study remaps Neanderthal and Denisovan genomes onto new and old references, finds improved mapping with T2T-CHM13, and identifies new introgressed sequences and population-specific archaic ancestry.

Genome biology · Feb 17, 2025Peer-reviewedEvolutionary Biology

Comparative transcriptome in rhesus macaques and crab-eating macaques

Yuxiang Mao, 中国科学院神经科学研究所神经科学国家重点实验室, 脑科学与智能技术卓越创新中心, 上海 200031, 中国, Yamei Li, Zikun Yang, Ning Xu, Shilong Zhang, Xuankai Wang, Xiangyu Yang, Qiang Sun, Yafei Mao, 上海脑科学与类脑研究中心, 上海 201210, 中国, 中国科学院大学, 北京 100049, 中国, 中国科学院遗传进化与动物模型重点实验室, 云南昆明 650201, 中国, 上海交通大学Bio-X研究院, 遗传发育与精神神经疾病教育部重点实验室, 上海 200030, 中国, 上海交通大学致远学院, 上海 200240, 中国, 浙江大学医学院附属第四医院, 国际健康医学研究院, 基因组研究中心, 浙江义乌 322000, 中国

This study compares transcriptomes between rhesus and crab-eating macaques and with humans, finding gene expression differences and overlaps with structural variants.

动物学研究 · Dec 28, 2023Peer-reviewedBioinformatics

A refined characterization of large-scale genomic differences in the first complete human genome

Xiangyu Yang, Xuankai Wang, Yawen Zou, Shilong Zhang, Manying Xia, Mitchell Robert Vollger, Nae-Chyun Chen, Dylan J. Taylor, William T. Harvey, Glennis A. Logsdon, Dan Meng, Junfeng Shi, Rajiv C. McCoy, Michael C. Schatz, Weidong Li, , Yafei Mao

The paper identifies and categorizes large-scale genomic differences between the T2T-CHM13 and GRCh38 human genome assemblies, highlighting their implications for disease and evolution.

bioRxiv · Dec 17, 2022 · PreprintGenomics