Author

Yuan He

Fudan University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biology Disciplines

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Genomics· 3 Cell Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 2 Research Focus:eQTL / molecular QTL mapping· 2 Research Focus:gene regulatory network inference· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Xiao Li· 3 shared Alexis J. BattleiD· 2 shared Andrew A. Brown· 2 shared Ayellet V. Segrè· 2 shared Barbara Elizabeth EngelhardtiD· 2 shared Benjamin J. Strober· 2 shared Christine B. Peterson· 2 shared Christopher D. BrowniD· 2 shared

Activity by Year

2016-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenomics

Xiao Li

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Author profile →

5 papers

Recent·Most cited

Goblet cells mechanically breach the epithelial barrier in gut homeostasis

Justine Creff, Yuan He, Sandra Bernat-Fabre, Étienne Buscail, Salomé Neuvendel, Vishnu Krishnakumar, Dhriti Saumya, Laurent Malaquin, Thomas Mangeat, Shi-Lei Xue, Denis Krndija

This study shows that goblet cells create tight junction fractures between enterocytes, increasing gut permeability under homeostatic conditions and during hypertrophy.

DOAJ (DOAJ: Directory of Open Access Journals) · Jul 25, 2026Peer-reviewedCell Biology

A Refined Analysis of Neanderthal-Introgressed Sequences in Modern Humans with a Complete Reference Genome

Shen-Ao Liang, Tianxin Ren, Jiayu Zhang, Jiahui He, Xuankai Wang, Xinrui Jiang, Yuan He, Rajiv C. McCoy, Qiaomei Fu, Joshua M. Akey, Yafei Mao, Lu Chen

This study remaps Neanderthal and Denisovan genomes onto new and old references, finds improved mapping with T2T-CHM13, and identifies new introgressed sequences and population-specific archaic ancestry.

Genome biology · Feb 17, 2025Peer-reviewedEvolutionary Biology

Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics

Alvaro Barbeira, Scott P. Dickinson, Rodrigo Bonazzola, Jiamao Zheng, Heather E. Wheeler, Jason M. Torres, Eric S. Torstenson, Kaanan P. Shah, Tzintzuni Garcia, Todd L. Edwards, Eli Stahl, Laura M. Huckins, François Aguet, Kristin Ardlie, Beryl B. Cummings, , Benjamin J. Strober

The paper develops S-PrediXcan to compute gene expression associations from GWAS summary data and applies it to 44 GTEx tissues and 100+ phenotypes, finding tissue-specific effects and colocalized associations.

Nature Communications · May 2, 2018Peer-reviewedGenomics

Distant regulatory effects of genetic variation in multiple human tissues

Brian Jo, Yuan He, Benjamin J. Strober, Princy Parsana, François Aguet, Andrew A. Brown, Stephane E. Castel, Eric R. Gamazon, Ariel Gewirtz, Genna Gliner, Buhm Han, Amy Z. He, Eun Yong Kang, Ian C. McDowell, Xiao Li, , Alexis Battle

The paper identifies trans-eQTLs in multiple human tissues and shows their tissue-specific effects and association with disease.

bioRxiv · Sep 9, 2016 · PreprintGenomics

Local genetic effects on gene expression across 44 human tissues

François Aguet, Andrew A. Brown, Stephane E. Castel, Joe R. Davis, Pejman Mohammadi, Ayellet V. Segrè, Zachary Zappala, Nathan S. Abell, Laure Frésard, Eric R. Gamazon, Ellen Gelfand, Michael J. Gloudemans, Yuan He, Farhad Hormozdiari, Xiao Li, , Stephen B. Montgomery

This study identifies cis-eQTLs across 44 human tissues using GTEx data, showing 88% of genes have cis-eQTLs and demonstrating their utility in understanding complex trait etiology.

bioRxiv · Sep 9, 2016 · PreprintGenomics