Cancer BiologybioRxivPreprint
TGS1 mediates mRNA 5'-cap trimethylation to promote oxidative phosphorylation in acute myeloid leukaemia.
Valentina Miano, Giovanna Carrà, Maxim Bouvet…·Isaia Barbieri
This study identifies TGS1 as a methyltransferase that modifies mRNAs encoding mitochondrial proteins in AML, promoting oxidative phosphorylation and cell survival, and shows its potential as a therapeutic target.
DOI 10.64898/2026.03.18.712389