Angelo D’Angelo

The paper identifies late endosomes as selective RNA carriers in motor neurons and shows that ALS-linked FUS mutations disrupt this process.

This study identifies TGS1 as a methyltransferase that modifies mRNAs encoding mitochondrial proteins in AML, promoting oxidative phosphorylation and cell survival, and shows its potential as a therapeutic target.

This study shows that mutant FUS reduces ALKBH5 expression, increasing m6A levels, and that restoring m6A alleviates ALS pathology in Drosophila models.

This paper identifies low-complexity repeats as key drivers of RNA-RNA interactions and introduces RIME, a deep learning model that outperforms traditional methods in predicting these interactions.

This study identifies HSCHARME, a lncRNA altered in cardiomyopathies, which promotes cardiomyocyte differentiation through splicing regulation.