Author

Reena Murmu Nielsen

University of CopenhagenORCID 0000-0002-2828-7352Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Assay:imaging· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Changsi CaiiD· 4 shared Martin LauritzeniD· 4 shared Bjørn Olav HaldiD· 3 shared Jonas Christoffer FordsmanniD· 3 shared Stefan Andreas ZambachiD· 3 shared Kirsten J. Thomsen· 2 shared Micael LønstrupiD· 2 shared Søren GrubbiD· 2 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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4 shared papersNeuroscience

Changsi CaiORCID

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4 papers

Recent·Most cited

Impaired dynamics of brain precapillary sphincters and first order capillaries explains reduced neurovascular functions in aging

Changsi Cai, Stefan Andreas Zambach, Søren Grubb, Kirsten J. Thomsen, Barbara Lykke Lind, Bjørn Olav Hald, Micael Lønstrup, Reena Murmu Nielsen, Martin Lauritzen

This study identifies age-related impairments in brain microvascular dynamics, particularly in precapillary sphincters, leading to reduced neurovascular function in aging.

bioRxiv · Aug 5, 2021 · PreprintNeuroscience

Nitric oxide, KATP channels and endothelin-1 modulate brain pericyte function, vascular tone and neurovascular coupling

Stefan Andreas Zambach, Changsi Cai, Hans Christian Cederberg Helms, Bjørn Olav Hald, Jonas Christoffer Fordsmann, Reena Murmu Nielsen, Micael Lønstrup, Birger Brodin, Martin Lauritzen

The paper investigates how nitric oxide, endothelin-1, and KATP channels modulate brain pericyte function, vascular tone, and neurovascular coupling through distinct signaling pathways.

bioRxiv · Jun 7, 2020 · PreprintNeuroscience

Sensory Stimulation-Induced Astrocytic Calcium Signaling in Electrically Silent Ischemic Penumbra

Reena Murmu Nielsen, Jonas Christoffer Fordsmann, Changsi Cai, Alexey Brazhe, Kirsten J. Thomsen, Martin Lauritzen

This study shows that somatosensory stimulation evokes astrocytic calcium signaling in the ischemic penumbra, with preserved responses in aged mice, suggesting astrocytic activity may contribute to neuroprotection after stroke.

Frontiers in Aging Neuroscience · Aug 21, 2019Peer-reviewedNeuroscience

Precapillary sphincters control cerebral blood flow

Søren Grubb, Changsi Cai, Bjørn Olav Hald, Lila Khennouf, Jonas Christoffer Fordsmann, Reena Murmu Nielsen, Aske G. K. Jensen, Stefan Andreas Zambach, Martin Lauritzen

This study identifies precapillary sphincters as regulators of cerebral blood flow, showing their dilation and constriction in response to neural activity and ischemia.

bioRxiv · Jun 5, 2019 · PreprintNeuroscience