Changsi Cai

This paper designs a deep learning-generated hASIC1a inhibitor that reduces infarct volume by over 50% in a mouse stroke model.

This study shows that astrocytes and neurons respond differently to intracortical microstimulation, with astrocytes showing spatially heterogeneous and temporally variable responses.

This study investigates how impaired calcium signaling in precapillary sphincters and pericytes contributes to neurovascular uncoupling after ischemic stroke in mice.

This study investigates how dual-electrode intracortical stimulation modulates neural activity in mice, finding intensity- and spatial-dependent neuromodulation effects.

This study identifies distinct Ca2+ signaling profiles in leptomeningeal fibroblast subgroups in awake mice under health and inflammation conditions.

This study investigates the spatial and temporal mismatch between neuronal activity and blood flow responses to intracortical microstimulation in mice, finding that low intensity stimulation preserves neurovascular coupling while high intensity causes mismatched responses and potential ischemia.

This study shows that neurovascular coupling in aged mice is slower and prolonged, with reduced Ca2+ signaling in vascular mural cells, and correlates with decreased spontaneous locomotion.

This study identifies age-related impairments in brain microvascular dynamics, particularly in precapillary sphincters, leading to reduced neurovascular function in aging.

The paper investigates how nitric oxide, endothelin-1, and KATP channels modulate brain pericyte function, vascular tone, and neurovascular coupling through distinct signaling pathways.

This study shows that somatosensory stimulation evokes astrocytic calcium signaling in the ischemic penumbra, with preserved responses in aged mice, suggesting astrocytic activity may contribute to neuroprotection after stroke.

This study identifies precapillary sphincters as regulators of cerebral blood flow, showing their dilation and constriction in response to neural activity and ischemia.