Alexander Michael Clifford

SH2scan quantifies ligand-SH2 domain interactions across >80% of targets, revealing binding selectivity and KDs to aid in designing selective inhibitors and degraders.

This study shows that gill ionocyte remodeling, not changes in gene expression, enables rockfish to maintain blood pH under hypercapnia by increasing membrane surface area for H+ excretion.

This paper analyzes the genome of Osedax frankpressi to show how genetic changes enable symbiotic digestion of bone, with reduced immunity genes and expanded protease genes.