Author

Hariharakrishnan Chidambaram

National Chemical LaboratoryORCID 0000-0002-2842-3342Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Research Focus:cell-cell communication· 1 Approach:mechanistic / dynamical model· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Subashchandrabose ChinnathambiiD· 4 shared Smita Eknath Desale· 2 shared Abhishek Ankur BalmikiD· 1 shared Kapali Suri· 1 shared N. Arul MuruganiD· 1 shared Rashmi Ranjan DasiD· 1 shared Shweta Kishor Sonawane· 1 shared Tazeen Qureshi· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 16 mutual co-author links

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4 shared papersNeuroscience

Subashchandrabose ChinnathambiORCID

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4 papers

Recent·Most cited

NeuroscienceBrain Network DisordersPeer-reviewedFeb 11, 2025

LC3-associated endocytosis facilitates extracellular Tau aggregate internalization and degradation in microglia

Hariharakrishnan Chidambaram, Subashchandrabose Chinnathambi

This study shows that microglia use LC3-associated endocytosis (LANDO) to internalize and degrade extracellular Tau aggregates via lysosomal fusion.

25 citationstop 1%

mouseexperimental assay

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Cell BiologybioRxivPreprintDec 4, 2024

Extracellular HDAC6 ZnF UBP domain enhances podosome-mediated neuronal migration

Tazeen Qureshi, Smita Eknath Desale, Shweta Kishor Sonawane…·Subashchandrabose Chinnathambi

The paper investigates the role of HDAC6 ZnF UBP domain in enhancing podosome-mediated neuronal migration through actin remodelling.

2 citations

proteomicsexperimental assay

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Cell BiologybioRxivPreprintDec 3, 2024

Microglia undergoes chemokine receptor, CX3CR1-mediated internalization of extracellular Tau

Hariharakrishnan Chidambaram, Smita Eknath Desale, Kapali Suri…·Subashchandrabose Chinnathambi

This study investigates how CX3CR1 mediates Tau internalization by microglia and how AZD8797 modulates this interaction through molecular docking and dynamics simulations.

3 citations

humanproteomics

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NeuroscienceEuropean Journal of Cell BiologyPeer-reviewedJan 25, 2022

G-Protein coupled Purinergic P2Y12 receptor interacts and internalizes TauRD-mediated by membrane-associated actin cytoskeleton remodelling in microglia

Hariharakrishnan Chidambaram, Rashmi Ranjan Das, Subashchandrabose Chinnathambi

This study shows that microglial P2Y12 receptor interacts with TauRD and mediates its internalization via actin remodeling, leading to microglial activation.

58 citations

humanproteomics

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