Federica Raguseo

The paper identifies a covalent fragment inhibitor of TYMS that selectively kills ATRX-deficient cells through replication stress.

This study shows that DNA secondary structures like G4s and iMs cause replication fork arrest and breakage, and that Pif1 helicase is required to resolve stalled forks.

The paper designs a synthetic signaling network that mimics immune cell responses to bacterial metabolism through coordinated synthetic agents.