Katrin Rittinger

Determinants of cysteine coverage by chemoproteomics

This study identifies factors governing cysteine detection in chemoproteomics using machine learning and statistical filtering, showing that peptide properties and abundance are key determinants.

Phenotype-first covalent fragment screening identifies a synthetic lethal TYMS inhibitor in ATRX-deficient cells

The paper identifies a covalent fragment inhibitor of TYMS that selectively kills ATRX-deficient cells through replication stress.

Conformational dynamics of the bacterial E3 ligase SspH1

This study presents the crystal structure of SspH1 and analyzes its conformational dynamics, showing it exists in an open-closed equilibrium with substrate binding modulating state distribution but not inducing major conformational changes.

Identification of RING E3 pseudoligases in the TRIM protein family

The paper identifies RING E3 pseudoligases in the TRIM protein family by analyzing their structure and ubiquitin ligase activity, revealing structural divergence that impairs their function.

Salmonella effector kinase SteC is activated by host-mediated phosphorylation

This study identifies that Salmonella effector kinase SteC is activated by host-mediated phosphorylation at S379, which enhances its kinase activity and promotes actin polymerisation.

Robust proteome profiling of cysteine-reactive fragments using label-free chemoproteomics

This paper develops a label-free chemoproteomics platform to profile cysteine-reactive fragments, identifying over 400 ligand-protein interactions in two cell lines.