This study investigates how psychoactive drugs alter the global workspace of consciousness by analyzing resting-state fMRI data, finding distinct changes in synergistic and redundant interactions across drug types.

bioRxiv · Oct 5, 2026 · PreprintNeuroscience

Ultrasonic potentiation of ketamine neuromodulation

Kanchan Sinha Roy, Payton J. Martinez, Sedona N. Ewbank, Kenneth Shinozuka, Mahaveer Prasad Purohit, Yun Xiang, Raag D. Airan

This paper shows that focused ultrasound enhances ketamine's neuromodulatory effects, with localized delivery via SonoKet achieving greater neurotransmitter changes at lower doses.

bioRxiv · Aug 4, 2026 · PreprintPharmacology & Toxicology

Ibogaine is associated with reorganization of high-beta brain networks in veterans with post-traumatic stress disorder

Kenneth Shinozuka, Mattia Rosso, Anna Chaiken, Jennifer I. Lissemore, Reece Jones, Nelson Descalço, Venkatesh Subramani, Maarten Belgers, Kirsten N. Cherian, Martijn Arns, Davide Momi, Raag D. Airan, Leonardo Bonetti, Arnt Schellekens, Maheen M. Adamson, , Camarin E. Rolle

This study shows that ibogaine treatment in PTSD veterans is linked to reorganization of high-beta brain networks, which correlates with symptom improvement.

bioRxiv · Mar 24, 2026 · PreprintNeuroscience

Neuroelectrophysiological correlates of extended cessation of consciousness in advanced meditators: A multimodal EEG and MEG study

Kenneth Shinozuka, Winson Fu Zun Yang, Ruby M. Potash, Terje Sparby, Matthew D. Sacchet

This study examines the neuroelectrophysiological correlates of extended cessation (EC) in meditators using EEG and MEG, finding increased high-frequency global coherence during EC compared to other unconscious states.

bioRxiv · Sep 19, 2025 · PreprintNeuroscience

The Role of the Dorsolateral Prefrontal Cortex in Ego Dissolution and Emotional Arousal During the Psychedelic State

Clayton R. Coleman, Kenneth Shinozuka, Robert Tromm, Ottavia Dipasquale, Mendel Kaelen, Leor Roseman, Suresh D Muthukumaraswamy, David John Nutt, Lionel Barnett, Robin Lester Carhart-Harris

This study uses fMRI and MEG to investigate how LSD affects DLPFC connectivity and relates to ego dissolution and emotional arousal in healthy humans.

Human Brain Mapping · Apr 1, 2025Peer-reviewedNeuroscience

LSD reconfigures the frequency-specific network landscape of the human brain

Kenneth Shinozuka, Mattia Rosso, Clayton R. Coleman, Leor Roseman, Mendel Kaelen, Suresh D Muthukumaraswamy, David Nutt, Robin Lester Carhart-Harris, Peter Vuust, Morten L. Kringelbach, Leonardo Bonetti

This study uses MEG data to show LSD reconfigures brain network frequencies and spatial distributions in specific frequency bands across different experimental conditions.

bioRxiv · Mar 21, 2025 · PreprintNeuroscience

LSD flattens the hierarchy of directed information flow in fast whole-brain dynamics

Kenneth Shinozuka, Prejaas K. B. Tewarie, Andrea I. Luppi, Christopher W. Lynn, Leor Roseman, Suresh D Muthukumaraswamy, David John Nutt, Robin Lester Carhart-Harris, Gustavo Deco, Morten L. Kringelbach

This study shows LSD reduces directed information hierarchy in the brain by balancing signal sending and receiving, as measured by MEG data.

Imaging Neuroscience · Dec 10, 2024Peer-reviewedNeuroscience

Synergistic, Multi-level Understanding of Psychedelics: Three Systematic Reviews and Meta-analyses of Their Pharmacology, Neuroimaging and Phenomenology

Kenneth Shinozuka, Katarina Jerotic, Pedro A. M. Mediano, Alex T. Zhao, Katrin H. Preller, Robin Lester Carhart-Harris, Morten L. Kringelbach

Translational Psychiatry · Dec 4, 2024Peer-reviewedNeuroscience