David Nutt

This study links synaptic vesicle density measured by PET with structural and functional neuroplasticity markers using multimodal imaging and EEG in healthy volunteers.

This study identifies structural and functional MRI differences in Gambling Disorder compared to healthy controls, highlighting brain regions and connectivity patterns associated with the disorder.

This study compares how psilocybin and escitalopram affect brain reconfiguration in MDD patients using whole-brain models and perturbation analysis.

This study compares brain responses to psilocybin and escitalopram in depression using the Fluctuation-Dissipation Theorem, finding distinct non-equilibrium dynamics and responder differentiation.

This study investigates brain changes after a single high-dose psilocybin administration, finding anatomical and functional alterations linked to improved well-being and cognitive flexibility.

This study uses computational models to simulate psychedelic treatments for disorders of consciousness, finding they shift brains closer to criticality, with varying effects based on patient state.

This study examines how LSD and MDMA affect striato-cortical connectivity in healthy subjects using resting-state fMRI, finding distinct changes in connectivity patterns between the striatum and other brain regions.

This paper applies whole-brain models to study state transitions in depression following psilocybin and escitalopram treatments, showing differential effects on susceptibility and drivability to healthier states.

This paper introduces graphTRIP, a geometric deep learning model that predicts antidepressant treatment response using neuroimaging and clinical data, identifying biomarkers and causal mechanisms.

This study uses multimodal imaging to show ketamine increases glutamate in the ACC and alters brain network connectivity, suggesting potential long-term neuroplastic effects.

This study uses fMRI and MEG to investigate how LSD affects DLPFC connectivity and relates to ego dissolution and emotional arousal in healthy humans.

This study uses MEG data to show LSD reconfigures brain network frequencies and spatial distributions in specific frequency bands across different experimental conditions.

This study shows LSD reduces directed information hierarchy in the brain by balancing signal sending and receiving, as measured by MEG data.

This paper investigates the long-term effects of psilocybin on fronto-striatal-thalamic circuit dynamics and connectivity using longitudinal fMRI data and computational modeling.

This paper models the transient brain state changes induced by DMT using a time-dependent whole-brain model and fMRI data, showing heightened reactivity in specific brain regions correlated with serotonin receptor density.

This study examines how external stimuli modulate brain entropy during a psychedelic experience, finding that eye closure enhances entropy changes and that video stimuli disrupt the relationship between brain activity and subjective experience.

The paper identifies brain regions and networks predictive of response to psilocybin therapy for treatment-resistant depression using whole-brain modeling and dynamic sensitivity analysis.

HADES framework analyzes spacetime activity patterns in the brain, showing reduced low-frequency harmonic modes during DMT-induced states, indicating changes in functional hierarchy.

This study shows that psilocybin therapy increases low-frequency brain responses to music in patients with treatment-resistant depression, correlating with subjective drug effects.

This study investigates how LSD affects reinforcement learning in humans by examining changes in learning rates, reinforcement sensitivity, and exploratory behavior during a probabilistic reversal learning task.

This paper shows that LSD and psilocybin reduce brain control energy and increase entropy by flattening the brain's energy landscape, using network control theory and PET data.

This study examines how CBD and THC affect striato-cortical connectivity in the human brain using fMRI, finding THC disrupts connectivity while CBD mitigates some effects and has mixed impacts when used alone.

This study investigates how DMT alters cortical travelling waves during a resting state, finding reduced backward and increased forward waves, supporting a model of altered precision-weighting of priors.

This study examines how IV DMT affects EEG brain activity, finding reduced alpha/beta power and increased signal diversity, with delta/theta activity correlating with peak subjective experience.

This study examines how psilocybin alters brain dynamics by analyzing functional connectivity states in fMRI data, finding enhanced global synchronization and reduced fronto-parietal control.

The paper investigates how cerebral blood flow changes in response to drugs targeting different neurotransmitter systems and finds a reliable spatial link between blood flow changes and receptor densities.

This study investigates how LSD affects brain activity during music listening, finding increased cortical and subcortical activity linked to timbral complexity and enhanced emotional responses.