Robin Lester Carhart-Harris

Serotonergic psychedelics delay resting state neurovascular coupling dynamics

This study shows serotonergic psychedelics like LSD and DMT delay resting state neurovascular coupling, affecting hemodynamic delays and functional connectivity in brain regions with serotonin receptors.

Psychedelics restructure information in the human brain

This study uses multivariate information decomposition to analyze how five psychedelics alter information processing in the human brain, revealing new insights into neural reorganization.

LSD Reconfigures Cortical Dynamics Through Faster Brain Rhythms and Increased Fractal Dimension

This study investigates how LSD alters brain dynamics using MEG and machine learning, finding increased peak frequencies, reduced oscillatory power, and changes in spectral complexity.

Spiral brain dynamics track the temporal unfolding of subjective intensity during the N,N-dimethyltryptamine experience

This study introduces vorticity-based metrics to analyze brain dynamics during DMT experiences, finding increased rotational organization and spatial heterogeneity associated with subjective intensity changes.

Psychedelics Align Brain Activity with Context

This study shows psilocybin reorganizes brain activity into context-sensitive patterns linked to subjective experience and mindset changes.

Divergent changes in perturbation-induced brain reconfiguration following depression treatment with psilocybin and escitalopram

This study compares how psilocybin and escitalopram affect brain reconfiguration in MDD patients using whole-brain models and perturbation analysis.

Distinct brain responses to psilocybin and escitalopram in depression captured by the Fluctuation-Dissipation Theorem

This study compares brain responses to psilocybin and escitalopram in depression using the Fluctuation-Dissipation Theorem, finding distinct non-equilibrium dynamics and responder differentiation.

A Shared Entropic Axis Spans States of Consciousness Across Pharmacological and Clinical Conditions

The paper quantifies consciousness states using entropy across pharmacological and clinical fMRI data, finding a shared entropic axis spanning from low-entropy anaesthesia to high-entropy psychedelic and schizophrenia states.

LSD Relaxes Structural Constraints on Brain Dynamics: A Connectome Harmonic MEG Study

This study uses MEG and connectome harmonics to show LSD reduces structure-function coupling in low-frequency brain activity, linking this to ego dissolution and altered network dynamics.

Human brain changes after first psilocybin use

This study investigates brain changes after a single high-dose psilocybin administration, finding anatomical and functional alterations linked to improved well-being and cognitive flexibility.

A Mesoscale Framework for Psychedelic Drug Action in the Human Brain

This study investigates how five psychedelic drugs affect local brain synchrony and global functional connectivity using fMRI, finding disrupted local synchrony and enhanced global connectivity across all drugs.

A virtual clinical trial of psychedelics to treat patients with disorders of consciousness

This study uses computational models to simulate psychedelic treatments for disorders of consciousness, finding they shift brains closer to criticality, with varying effects based on patient state.

Complexity as a Potential Neurophysiological Correlate of Awe

This study investigates the neurophysiological correlates of awe using EEG, finding increased complexity in neural signals during awe experiences, though with limited generalization to other datasets.

Dissociable effects of LSD and MDMA on striato-cortical connectivity in healthy subjects

This study examines how LSD and MDMA affect striato-cortical connectivity in healthy subjects using resting-state fMRI, finding distinct changes in connectivity patterns between the striatum and other brain regions.

Perturbing whole-brain models of brain hierarchy: an application for depression following pharmacological treatment

This paper applies whole-brain models to study state transitions in depression following psilocybin and escitalopram treatments, showing differential effects on susceptibility and drivability to healthier states.

Accurate and Interpretable Prediction of Antidepressant Treatment Response from Receptor-informed Neuroimaging

This paper introduces graphTRIP, a geometric deep learning model that predicts antidepressant treatment response using neuroimaging and clinical data, identifying biomarkers and causal mechanisms.

Detecting neuroplastic effects induced by ketamine in healthy human subjects: a multimodal approach

This study uses multimodal imaging to show ketamine increases glutamate in the ACC and alters brain network connectivity, suggesting potential long-term neuroplastic effects.

Time-resolved network control analysis links reduced control energy under DMT with the serotonin 2a receptor, signal diversity, and subjective experience.

This study uses network control theory to show DMT reduces brain control energy, correlates with EEG entropy and subjective experience, and links these effects to serotonin 2a receptor distribution.

The Role of the Dorsolateral Prefrontal Cortex in Ego Dissolution and Emotional Arousal During the Psychedelic State

This study uses fMRI and MEG to investigate how LSD affects DLPFC connectivity and relates to ego dissolution and emotional arousal in healthy humans.

LSD reconfigures the frequency-specific network landscape of the human brain

This study uses MEG data to show LSD reconfigures brain network frequencies and spatial distributions in specific frequency bands across different experimental conditions.

Revealing Changes in Linear and Nonlinear Functional Connectivity After Psilocybin and Escitalopram Treatment in Patients with Depression

This study compares changes in linear and nonlinear functional connectivity in MDD patients after psilocybin or escitalopram treatment, finding distinct patterns between responders and non-responders.

DMT-induced shifts in criticality correlate with ego-dissolution

This study examines how DMT affects brain oscillation criticality and links these changes to ego-dissolution experiences.

Dynamic medial parietal and hippocampal deactivations under DMT relate to sympathetic output and altered sense of time, space, and the self

This study identifies brain substates and autonomic correlates during DMT administration, linking hippocampal and medial parietal deactivations to altered consciousness and sympathetic output.

Brain dynamics of classical psychedelics show paradoxical hierarchical flattening with increased complexity

This study examines how classical psychedelics alter brain hierarchy and complexity, finding they reduce hierarchy while increasing neural complexity.

Diminished functional gradient of the precuneus during altered states of consciousness

The paper examines functional connectivity gradients in the posterior precuneus during altered states of consciousness, finding continuous connectivity patterns that flatten in these states.

LSD flattens the hierarchy of directed information flow in fast whole-brain dynamics

This study shows LSD reduces directed information hierarchy in the brain by balancing signal sending and receiving, as measured by MEG data.

Synergistic, Multi-level Understanding of Psychedelics: Three Systematic Reviews and Meta-analyses of Their Pharmacology, Neuroimaging and Phenomenology

Long-term effects of psilocybin on dynamic and effectivity connectivity of fronto-striatal-thalamic circuits

This paper investigates the long-term effects of psilocybin on fronto-striatal-thalamic circuit dynamics and connectivity using longitudinal fMRI data and computational modeling.

Autonomic Nervous System activity correlates with peak experiences induced by DMT and predicts increases in wellbeing

A Synergistic Workspace for Human Consciousness Revealed by Integrated Information Decomposition

This paper proposes a synergistic global workspace model of consciousness using network science and information theory, showing that loss of consciousness correlates with reduced information integration in specific brain networks.