Therapeutic potential of oxygen through M101 transportation in reducing vaso-occlusion and hemolysis in a mouse model of sickle cell disease.
Franck Zal, Rachel Rignault‐Bricard, Leïla Demini, Benoı̂t Barrou, Laurent Alexandre Lantieri, Olivier Hermine, Jean‐Benoît Arlet, Thiago Trovati Maciel
This study evaluates M101, a marine-derived hemoglobin-based oxygen carrier, in a mouse model of sickle cell disease, showing reduced RBC sickling, hemolysis, and vaso-occlusion.
bioRxiv · Jun 18, 2025 · PreprintPathology