Olivier Hermine

This paper demonstrates that masitinib achieves sufficient CNS concentrations to inhibit key targets in progressive MS, showing neuroprotective effects and potential as a treatment.

This study identifies clonal lymphocyte expansions and JAK-STAT mutations in celiac disease subtypes, revealing shared mechanisms and limitations of JAK inhibitor therapy.

This study identifies AXL as a driver of mast cell survival and TKI resistance in mastocytosis and shows that dual KIT/AXL inhibition restores TKI sensitivity.

This study investigates VEXAS anemia, showing that UBA1 mutations affect erythroblast differentiation but not mature red cells, leading to a mosaic erythroblastopenia.

This study investigates how Neuropilin-1 (NRP-1) on solid tumors affects CAR T cell function, finding that NRP-1 transfer via trogocytosis may impair CAR T cell activity.

This study evaluates M101, a marine-derived hemoglobin-based oxygen carrier, in a mouse model of sickle cell disease, showing reduced RBC sickling, hemolysis, and vaso-occlusion.

This study identifies molecular and cellular changes in storage-induced senescent erythrocytes (SMEs) that lead to their clearance, showing altered metabolism, proteostasis, and membrane properties.

The paper identifies CTL2 deficiency in humans causing hearing loss, arterial aneurysms, and epilepsy, while showing normal platelet function and erythropoiesis.

This study shows that Tax and HBZ, viral oncoproteins, alter mRNA splicing in T-cells by interacting with spliceosome components, leading to changes in cancer-related genes.

PCIP-seq uses long-read sequencing to simultaneously identify retroviral insertion sites and their integrated proviruses, revealing SNPs, structural variants, and viral evolution.

The paper identifies a mutation in Cdc42 that causes a severe autoinflammatory syndrome by trapping the protein in the Golgi and disrupting its membrane interaction.