Author

Patrick L. Holland

Yale UniversityORCID 0000-0002-2883-2031Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Allen C. GaoiD· 1 shared Anthony TigheiD· 1 shared Beat C. BornhauseriD· 1 shared Brandon Q. MercadoiD· 1 shared Christopher R. VakociD· 1 shared Debanjan BhattacharjeeiD· 1 shared Emily Scheib· 1 shared Erin L. SausvilleiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Allen C. GaoORCID

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1 paper

Recent·Most cited

Cancer BiologybioRxivPreprintNov 26, 2025

A clinical-stage oncology compound selectively targets drug-resistant cancers

Kaitlin Long, Debanjan Bhattacharjee, Samuel H. Newman-Stonebraker…·Jason M. Sheltzer

This study reveals that PAC-1, a clinical-stage oncology compound, targets drug-resistant cancers by disrupting iron homeostasis and exploiting MDR1 expression to induce iron depletion.

DOI 10.1101/2025.11.26.690878

experimental assaybiophysical modeling

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