Frem1 activity regulated by Sonic Hedgehog signaling in the cranial neural crest mesenchyme guides midfacial morphogenesis
Matthew Tomas McLaughlin, Miranda R. Sun, Tyler G. Beames, Austin C. Steward, Joshua W. M. Theisen, Hannah M. Chung, Joshua L. Everson, Ivan P. G. Moskowitz, Michael D. Sheets, Robert J. Lipinski
This study identifies Frem1 as a target of Sonic Hedgehog signaling in cranial neural crest cells, showing its role in midfacial morphogenesis and face shape variation.
bioRxiv · Jul 16, 2022 · PreprintDevelopmental Biology