Ivan P. G. Moskowitz

This study shows that Tbx3 and Tbx5 work together to control the function and molecular identity of the adult ventricular conduction system in mice, leading to conduction defects when both are missing.

This study identifies an arachidonic acid binding pocket in SMO that modulates SHH signaling, revealing context-specific allostery crucial for cardiopulmonary development.

The paper shows that NE ruptures occur before ECM signaling and disease in Lamin-cardiomyopathy mice without activating cGAS-STING.

This study integrates single-cell epigenomics with GWAS to identify risk variants and genes for Atrial Fibrillation, highlighting key transcription factors and pathways.

This paper identifies sequential phases of ETV2-dependent gene expression that drive hematoendothelial fate commitment from mesoderm progenitors.

This study identifies Hedgehog signaling as a regulator of differentiation timing through a heterochronic gene regulatory network in cardiac and neural lineages.

This study identifies Frem1 as a target of Sonic Hedgehog signaling in cranial neural crest cells, showing its role in midfacial morphogenesis and face shape variation.

This study identifies a gene regulatory network involving Tbx5, RA, Hedgehog, and Wnt signaling that coordinates cardiopulmonary development.

The paper introduces BioTIP, a method to identify critical transition signals in gene expression data, showing it accurately detects bifurcations and identifies key transcription factors involved in differentiation.

This study identifies a Hedgehog-FGF signaling axis critical for anterior mesoderm patterning during gastrulation using single-cell transcriptomics in Hh-deficient embryos.

The paper introduces a new computational pipeline, Tuxedo, for analyzing nuclear RNA-seq data, which identifies chromatin-enriched RNAs (cheRNAs) and characterizes their cis-regulatory roles.

The paper identifies cis-regulatory elements (CREs) for photoreceptor cell types using Nrl-dependent ncRNA profiling and ATAC-seq in mouse retina.

This study identifies Gata4's role in promoting Hh-signaling for proper SHF migration and OFT development, showing that Hh signaling rescues OFT defects in Gata4 mutants.

This study identifies a genetic variant at 1p32.2 that regulates endothelial responses to hemodynamics by modulating an enhancer region in vascular endothelium.

The paper generates promoter interaction maps in human iPSCs and cardiomyocytes to link CVD-associated SNPs to target genes, showing most SNPs interact with non-nearest genes.

This study identifies depolymerized LMNA as a mediator of mitotic transcriptional quiescence by linking nuclear envelope breakdown to transcriptional repression.