Author

Simeon Springer

ORCID 0000-0002-2891-2111Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Research Focus:dimensionality reduction· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Arthur P. Grollman· 2 shared Bahman Afsari· 2 shared Bert VogelsteiniD· 2 shared Christopher DouvilleiD· 2 shared Cristian Tomasetti· 2 shared George J. NettoiD· 2 shared Isaac Kinde· 2 shared Janine Ptak· 2 shared

Activity by Year

2017-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Arthur P. Grollman

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3 papers

Recent·Most cited

A novel functional gene delivery platform based on a commensal human anellovirus demonstrates transduction in multiple tissue types

Cato Prince, George S. Bounoutas, Bolu Zhou, Waseem Khan Raja, Isabella Gold, Riana Pozsgai, Parmi Thakker, Nicole M. Boisvert, Christopher Reardon, Stephanie Thurmond, Erin Ozturk, Rajendra Boggavarapu, Jenna M. Antonucci, Patricio Jeraldo, Simeon U. Springer, , Joseph M. Cabral

This paper develops a gene delivery vector based on a human anellovirus, demonstrating transduction in multiple tissues and durable in vivo function in mice.

Molecular Therapy — Methods & Clinical Development · Sep 23, 2025Peer-reviewedBioengineering

Non-invasive detection of bladder cancer through the analysis of driver gene mutations and aneuploidy

Simeon Springer, Maria Del Carmen Rodriguez Pena, Lu Li, Christopher Douville, Yuxuan Wang, Josh Cohen, Diana Taheri, Bahman Afsari, Natalie Silliman, Joy Schaeffer, Janine Ptak, Lisa Dobbyn, Maria Papoli, Isaac Kinde, Bahman Afsari, , George J. Netto

This paper develops a non-invasive urine-based test for bladder cancer detection using driver gene mutations and aneuploidy analysis, showing high sensitivity and specificity compared to cytology.

bioRxiv · Oct 16, 2017 · PreprintCancer Biology

Non-invasive detection of upper tract urothelial carcinomas through the analysis of driver gene mutations and aneuploidy in urine

Simeon Springer, Chung-Hsin Chen, Lu Li, Chris Douville, Yuxuan Wang, Josh Cohen, Bahman Afsari, Ludmila Danilova, Natalie Silliman, Joy Schaeffer, Janine Ptak, Lisa Dobbyn, Maria Papoli, Isaac Kinde, Chao-Yuan Huang, , Kathleen G. Dickman

This study develops a non-invasive test for upper tract urothelial carcinomas using urine-based molecular analysis of driver gene mutations and aneuploidy, showing high sensitivity compared to current methods.

bioRxiv · Oct 16, 2017 · PreprintCancer Biology