Bert Vogelstein

The paper designs an AND-gated CAR T cell receptor called MANTIS that uses extracellular size differences to spatially regulate signaling for precise antigen recognition.

This paper engineers effector cells resistant to bacterial toxins to deliver immunotoxins specifically to cancer cells and introduces a platform for therapeutic cell type development.

This study develops anti-9G4 CAR-T and TCR-T cells to selectively target autoreactive B cells in SLE, reducing immunosuppression and cytokine toxicity.

The paper identifies NXPE1 as a gene responsible for sialic acid O-acetylation in the human colon, linking it to mPAS staining differences through genetic and functional analyses.

A SMG1 inhibitor disrupts nonsense-mediated decay, increasing expression of neoantigens from truncating mutations and enhancing immune targetable peptides on cancer cells.

This paper develops a non-invasive urine-based test for bladder cancer detection using driver gene mutations and aneuploidy analysis, showing high sensitivity and specificity compared to cytology.

This study develops a non-invasive test for upper tract urothelial carcinomas using urine-based molecular analysis of driver gene mutations and aneuploidy, showing high sensitivity compared to current methods.