Path-dependent recovery of the gut microbiome after antibiotics emerges from coupled ecological and evolutionary dynamics
Chinmay K Lalgudi, Masakazu Kotaka, Eitan Yaffe, Jamie Alcira Lopez, Feiqiao Brian Yu, Katharine M. Ng, Justin Laine Sonnenburg, Benjamin H. Good, Kerwyn Casey Huang, Handuo Shi
This study shows that gut microbiome recovery after antibiotics is path-dependent, shaped by ecological and evolutionary dynamics including strain sweeps, genetic changes, and phage activity.
bioRxiv · May 23, 2026 · PreprintMicrobiology